The unlucky victim will be Hollyoaks favourite Amy Barnes, who only recently returned to the soap.
She moved back to the village last year with partner Ryan Knight and her two kids Leah and Lucas, after leaving in 2014.
But in a shocking plot teased in at the new trailer for the Channel 4 soap, there is a big death on the cards.
While details are being kept secret, it’s been revealed that Amy will die in the coming months as part of a new plot.
Hollyoaks Spoilers: Amy Barnes will be killed off in a shocking new storyline [Lime Pictures]
But what will happen to the young mum?
Ryan Knight will stumble upon his lifeless partner at their home according to reports, before he’s heard making a frantic call for help.
Audio from his emergency 999 call plays in the trailer, with Ryan heard saying: “Please, you need to help her. She’s not breathing. I think she’s dead.”
Amy has no idea Ryan recently cheated on her with Mercedes McQueen.
She also faced trouble with her ex Ste Hay over the custody of their children.
Ste suffered brain damage as a result of his drug taking, causing him to act out in blackouts.
Hollyoaks Spoilers: A new trailer teased Amy Barnes’ mystery death on the show [Lime Pictures]
Hollyoaks Spoilers: Ryan Knight will find his partner Amy Barnes dead [Lime Pictures]
While no details on the death have been revealed, has someone murdered the character and why?
Ste is seen telling her he wishes she was dead, and things get pretty heated – will he be in the frame?
Amy’s father Mike Barnes will also be devastated, with this being the second time he has lost a daughter.
Her sister Sarah was killed by her girlfriend Lydia during a skydive, when Lydia sabotaged her parachute.
Hollyoaks Spoilers: The trailer sees Ste Hay and Amy Barnes in a shocking showdown [Lime Pictures]
Lydia had planned to kill someone else, but in emotional scene Sarah took the wrong parachute.
This is set to be one of the biggest plots of the year, and knowing Hollyoaks there will no doubt be all sorts of twists and turns along the way.
Digital Spy confirmed the plot would see the demise of Amy after the trailer teased as much.
According to them, a source or the show confirmed the storyline and that Amy definitely dies as a result.
Hollyoaks: Will Ste Hay be behind Amy Barnes’ demise? [Lime Pictures]
They said the plot will focus on Amy’s mysterious death and who or what caused it – leaving fans guessing.
While the trailer doesn’t show Amy or confirm her death, a source told the site that Ryan was referring to Amy in his emergency call.